邢唷 > ? ? 欹 ] bjbjZ!Z! €2 8K4\8K4\ ( * 8 8 / / / C C C 8 { 4 C 狫 8 E " g g g -$ \ ? $ ? MJ OJ OJ OJ OJ OJ OJ 釲 極 & OJ / ? $ $ " ? ? OJ g g dJ ? ? ? ? @ g R g ]D ? ? MJ ? ? r ? T " ? g \鳛V ( E4 ID zJ 0 狫 S4 綪 ? 綪 ? 綪 / ? X ? ? ? ? ? ? ? ? OJ OJ #) f ? ? ? 狫 ? ? ? ? 綪 ? ? ? ? ? ? ? ? ? 8 I : Covalent Molecular Recognition via Iminoboronate ChemistryJianmin GaoDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USAMolecular recognition underlies essentially every aspect of biology and selective inhibition of culprit molecules has been the guiding philsophy of medicinal chemistry. In nature, seletive association of molecules are primarily driven by noncovalent interactions, while covalent bond formation has been largely avoided due to the potential difficulty of dissociation. We and others have been developing reversible covalent chemistries, which can give rise to powerful strategies for targeting biomolecules. HYPERLINK \l "_ENREF_1" \o "Bandyopadhyay, 2016 #2268" ADDIN EN.CITE Bandyopadhyay201622682268226817Bandyopadhyay, A.Gao, J.Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, United States.
Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, United States. Electronic address: jianmin.gao@bc.edu.亚星游戏yaxin333(有限公司)官方网站-Weixin百科Nature communicationsNature communicationsNat Commun62015Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.Articlehttp://dx.doi.org/10.1038/ncomms756110.1038/ncomms75613 a bacterial lipid reponsible for resistance to cationic antibiotics. The details of these developements will be discussed as well. We thank Boston College, the National Science Foundation and the National Institutes of Health for financial support.References ADDIN EN.REFLIST (1) Bandyopadhyay, A.; Gao, J. "Targeting biomolecules with reversible covalent chemistry" Curr Opin Chem Biol 2016, 34, 110-116. (2) Bandyopadhyay, A.; Gao, J. "Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators" J Am Chem Soc 2016, 138, 2098-2101. (3) Bandyopadhyay, A.; McCarthy, K. A.; Kelly, M. A.; Gao, J. "Targeting bacteria via iminoboronate chemistry of amine-presenting lipids" Nature communications 2015, 6.6561. PAGE PAGE 1The Gao GroupChemistryBoston College # 1 : ; F G v { 疣鹩嗥盯巟j\OE;EOE h%e PJ nHtH h&tN PJ nHtH hRT hRT PJ nHtH h' hAY 6丳J nHtHh' h? 6丳J nHtH*h嘷n hcH 5丳J aJ mH nHo(sH tH 'h嘷n h? 5丳J aJ mH nHsH tH&h嘷n hXHk 5丳J mH nHo(sH tH h嘷n hf 5丳J \乶HtH h 5丳J \乶HtH hQ g 5丳J \乶HtH h嘷n h%e 5丳J \乶HtH h嘷n h[! 5丳J \乶HtH ; G 6 8 9 Q } { gd d gd? d ^ ` gd? d ^ ` gd? d ｜ ^ ` gd $ d ^ ` a$gdtR $a$gdQ g $a$gd.2s $a$gd嘷n $ a$gd嘷n $a$gdz"
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w cIminoboronate 2
w r cChemistry
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W cJianmin Gao
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\ Y cDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA
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m\ c & 2
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% chave been explored in our laboratory L 2
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